Introduction: Nowadays empowerment of patient has a main role in health care and it is based on individual`s partnership in treatment process. Since patients` participation in self-care activities requires self- efficacy or in other words belief in their ability, so this study was conducted to examine relation between empowerment with self-care and self-efficacy on Gorgan hemodialysis patients.

Materials & Methods: This study is a descriptive and analytical study was done in 2011. 106 patients treated with hemodialysis center Panj Azar by census method were studied. Instruments includes demographic information, empowerment Scale (ES), Strategies Used by People to Promote Health (SUPPH) and self-care scale. Data were analyzed by SPSS-16 software using descriptive and inferential statistics (correlation and regression) at the significant level (p≤0.05).

Results: The results showed that the mean level of empowerment (21.73 ± 4.2) is low and also in regression analysis, Empowerment level has a significant relation with self-care (p< 0.048) and stress reduction dimension of self-efficacy (p<0.011) and there wasn’t significant relation between positive attitude (p<0.1) and decision making (p<0.28).

Discussions and Conclusions: There is a relationship between self-care and self-efficacy with empowerment and it is necessary to pay attention to self-efficacy and self-care behaviors’ education in order to improve of empowering patients.