Introduction: Burnout is one of the main outcomes of job stress. Probably, burnout is one of effective factors on quality of working life. If the relationship between them becomes apparent, managers can provide conditions for nurses to increase quality of working life and be more productive. The purpose of this study is to investigate the relationship burnout and quality of working life in nurses of AJA hospitals in Tehran. Materials and Methods: This research is a cross-sectional (descriptive-analytical) study that carried out on 322 clinical nurses working in AJA hospitals in Tehran. The subjects were recruited by multi-stages random sampling method in 2012-2013. Data was collected by using the Persian version of Burnout Maslach’s Inquiry and quality of working life’s questionnaire, and then analyzed through descriptive and analytical statistics by SPSS software (version 19).

Results: Findings showed a statistical reverse relationship between emotional exhaustion and personal accomplishment with quality of working life’s nurses (p=0.006).

Discussion and Conclusion: Majority of the nurses who participated in this study in term of burnout were in inappripriately conditions. Most of nurses had medium quality of working life score that these findings showed need to use useful strategies for them to increase quality of working life.