RT - Journal Article T1 - The Effectiveness of Memory Reconsolidation Interference by Propranolol on Craving and Emotion in Heroin Abusers JF - ajaums-mcs YR - 2021 JO - ajaums-mcs VO - 8 IS - 2 UR - http://mcs.ajaums.ac.ir/article-1-460-en.html SP - 156 EP - 168 K1 - Addiction K1 - Craving K1 - Emotion K1 - Memory Consolidation K1 - Propranolol AB - Introduction: A brief encounter with the cues associated with the drug leads to memory reconsolidation and disruption of drug memory by drug use can lead to memory update and reduced relapse. Objective: This study aimed at determining the effectiveness of memory reconsolidation interference by propranolol on drug craving and its relationship with emotion in subjects with heroin use disorder. Materials and Methods: This study was a quasi-experimental research with a pre-test-post-test and follow-up with a control group on 50 men (mean age 22 to 68 years) performed in Qom province addiction treatment camps in 2020. Data collection tools included demographic information questionnaire, structured diagnostic interview based on DSM.5, change readiness questionnaire, Bart impulsivity scale, computerized visual craving test, visual analog induction craving scale, and positive and negative emotion scale. Data were analyzed using SPSS software version 24 and multivariate analysis of variance tests with repeated measures and Pearson correlation at a significance level of less than P< 0.05. For the experimental group 10 minutes later from retrieval, propranolol (40 mg) was prescribed and the control group did not receive medication. Results: Repeated measures analysis of variance showed that interference in drug abuse memory reconsolidation by propranolol significantly reduced heroin induction craving in the experimental group as compared with the control group (P< 0.001). However, no statistically significant relationship was observed in pretest (P= 0.223, P= 0.08), posttest (P= 0.225, P= 0.186), and follow-up (P= 0.555, P= 0.018) between craving and positive or negative emotions. Discussion and Conclusion: The results of this study showed that neuroscience innovations can be used for the treatment of addiction disorders. LA eng UL http://mcs.ajaums.ac.ir/article-1-460-en.html M3 10.52547/mcs.8.2.156 ER -