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Effect of Vitamin D Supplementation on Increasing Bone Osteoblastic Activity in Conscript Soldiers during Military Training Course
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Hamid Khazdooz1    , Hamid Sadeghi * 2, Mohsen Ghasem Zadeh Soroush3 |
1- MD, Internal Medicine Specialist, Assistant Professor, Internal Medicine Department, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
2- MD, Internal Medicine, Researcher, Internal Diseases Department, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
3- MD, Associate Professor, Rheumatology Department, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran |
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Abstract: (995 Views) |
Introduction: Despite the great importance of bone health in military training course, there is a dearth of research in this regard.
Objective: The present study was conducted to investigate the effect of vitamin D supplementation on increasing bone osteoblastic activity in conscript soldiers during the military training course in one of the army training barracks of the IRI Army in 1400.
Material and Methods: This quasi-experimental before-and-after study was conducted on 60 soldiers who were randomly divided into two groups of 30, including the intervention and control groups. At the beginning of the training course, the soldiers of the intervention group were given a single dose oral supplement of 50,000 units of vitamin D. Soldiers were followed up for 40 days. Serum levels of vitamin D, calcium, phosphorus, bone alkaline phosphatase, and osteocalcin were measured before and after the training course.
Results: Before the training course, there was no significant difference between the two groups in terms of calcium (P=0.839), phosphorus (P=0.681), vitamin D (P=0.256), bone ALP (P=0.481), and osteocalcin (P=0.455). However, after the end of the course, the amount of vitamin D (P=0.034) and osteocalcin (P=0.003) was significantly higher in the intervention group, compared to the control group. In addition, the level of vitamin D (P=0.003) increased significantly in the intervention group at the end of the study.
Conclusion: At the end of this course, the level of osteocalcin in both groups increased, compared to the time before the treatment. This indicates that the physical activities in this training course do not have a destructive effect on the bones. This increase was higher in the group that received vitamin D supplements, showing the importance of proper nutrition and the use of supplements. |
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| Keywords: Bone, Military Personnel, Osteocalcin, Vitamin D |
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Full-Text [PDF 491 kb]
(229 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2022/06/6 | Accepted: 2022/08/10 | Published: 2022/09/1
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1. Sivakumar G, Koziarz A, Farrokhyar F. Vitamin D supplementation in military personnel: A systematic review of randomized controlled trials. Sports Health. 2019; 11(5): 425-31. [ DOI] [ PubMed] [ PubMed Central] 2. Miyamoto T, Oguma Y, Sato Y, Kobayashi T, Ito E, Tani M, et al. Elevated creatine kinase and lactic acid dehydrogenase and decreased osteocalcin and uncarboxylated osteocalcin are associated with bone stress injuries in young female athletes. Sci Rep. 2018; 8(1): 18019. [ DOI] [ PubMed] [ PubMed Central] 3. Lerchbaum E, Trummer C, Theiler-Schwetz V, Kollmann M, Wolfler M, Pilz S, et al. Effects of vitamin D supplementation on bone turnover and bone mineral density in healthy men: A post-Hoc analysis of a randomized controlled trial. Nutrients. 2019;11(4): 731. [ DOI] [ PubMed] [ PubMed Central] 4. Mathew J, Berger D, Tabatabaie V. Severe osteomalacia and fractures secondary to vitamin D deficiency. J Endocr Soc. 2021; 5(Supplement_1): A221. [ DOI] [ PubMed] 5. Seibel MJ. Biochemical markers of bone turnover: Part I: Biochemistry and variability. Clin Biochem Rev. 2005; 26(4): 97-122. [ DOI] [ PubMed] 6. Lutz LJ, Karl JP, Rood JC, Cable SJ, Williams KW, Young AJ, et al. Vitamin D status, dietary intake, and bone turnover in female Soldiers during military training: A longitudinal study. J Int Soc Sports Nutr. 2012; 9(1): 38. [ DOI] [ PubMed] [ PubMed Central] 7. Gaffney-Stomberg E, Hughes JM, Guerriere KI, Staab JS, Cable SJ, Bouxsein ML, et al. Once daily calcium (1000 mg) and vitamin D (1000 IU) supplementation during military training prevents increases in biochemical markers of bone resorption but does not affect tibial microarchitecture in Army recruits. Bone. 2022; 155: 116269. [ DOI] [ PubMed] 8. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999; 69(5): 842-56. [ DOI] [ PubMed] 9. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020; 12(4): 988. [ DOI] [ PubMed] [ PubMed Central] 10. Need AG, Horowitz M, Morris HA, Nordin BC. Vitamin D status: Effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women. Am J Clin Nutr. 2000; 71(6): 1577-81. [ DOI] [ PubMed] 11. Viljakainen H, Ivaska KK, Paldánius P, Lipsanen-Nyman M, Saukkonen T, Pietiläinen KH, et al. Suppressed bone turnover in obesity: A link to energy metabolism? A casecontrol study. T J Clin Endocrinol Metab. 2014;99(6):2155-63. 12. Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007; 115(7): 846-54. [ DOI] [ PubMed] 13. Timar A, Saberi-Karimian M, Ghazizadeh H, Parizadeh SMR, Sabbaghzadeh R, Emadzadeh M, et al. Evaluation of the serum prooxidant-antioxidant balance before and after vitamin D supplementation in adolescent Iranian girls. Adv Med Sci. 2019; 64(1): 174-80. [ DOI] [ PubMed] 14. Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr. 2011; 29(2): 149. [ DOI] [ PubMed] [ PubMed Central] 15. 15. Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K. Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res. 2008; 23(5) :741-9. [ DOI] [ PubMed] 16. Pihlajamäki H, Parviainen M, Kyröläinen H, Kautiainen H, Kiviranta I. Regular physical exercise before entering military service may protect young adult men from fatigue fractures. BMC Musculoskelet Disord. 2019; 20(1): 126. [ DOI] [ PubMed] [ PubMed Central] 17. Andersen NE, Karl JP, Cable SJ, Williams KW, Rood JC, Young AJ, et al. Vitamin D status in female military personnel during combat training. J Int Soc Sports Nutr. 2010;7:38. [ DOI] [ PubMed] [ PubMed Central] 18. 18. Fogleman SA, Janney C, Cialdella-Kam L, Flint JH. Vitamin D deficiency in the military: It’s time to act! Mil Med. 2022; 187(5-6): 144-8. [ DOI] [ PubMed] 19. 19. Chatzipapas C, Drosos G I, Kazakos K I, Tripsianis G, Iatrou C, Verettas D-A J. Stress fractures in military men and bone quality related factors. Int J Sports Med. 2008; 29(11): 922-6. [ DOI] [ PubMed] 20. Gaffney-Stomberg E, Lutz LJ, Rood JC, Cable SJ, Pasiakos SM, Young AJ, et al. Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial. Bone. 2014;68:46-56. [ DOI] [ PubMed] 21. Pilch W, Kita B, Piotrowska A, Tota Ł, Maciejczyk M, Czerwińska-Ledwig O, et al. The effect of vitamin D supplementation on the muscle damage after eccentric exercise in young men: A randomized, control trial. Journal of the International Society of Sports Nutrition. 2020; 17(1): 53. [ DOI] 22. Frank LL, McCarthy MS. Telehealth oaching: Impact on dietary and physical activity contributions to bone health during a military deployment. Mil Med. 2016; 181(5 Suppl): 191-8. [ DOI] [ PubMed] 23. Hughes JM, Smith MA, Henning PC, Scofield DE, Spiering BA, Staab JS, et al. Bone formation is suppressed with multi-stressor military training. Eur J Appl Physiol. 2014;114(11):2251-9. [ DOI] [ PubMed] 24. Li J, Zhang H, Yang C, Li Y, Dai Z. An overview of osteocalcin progress. J Bone Miner Metab. 2016; 34(4): 367-79. [ DOI] [ PubMed] |
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Ethics code: IR.AJAUMS.REC.1400.127
Khazdooz H, Sadeghi H, Ghasem Zadeh Soroush M. Effect of Vitamin D Supplementation on Increasing Bone Osteoblastic Activity in Conscript Soldiers during Military Training Course. MCS 2022; 9 (2) :103-110 URL: http://mcs.ajaums.ac.ir/article-1-539-en.html
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