Introduction: brucellosis is a disease common to humans and animals, with social and economic importance, causing physical symptoms and disability, which can impose health care costs. Prevention, control and eradication of brucellosis in a country or region require policy-making and careful planning based on accurate epidemiological data.

Objectives: the purpose of this study was to evaluate the 10-year trend of the disease in the city of Tiran & Karvan, Iran.

Materials and Methods: This was a cross-sectional study in which data of all the cases detected with brucellosis in Tiran & Karvan during 2004-2013, reported by the government and NGOs, were collected and then analyzed with computer. From a total of 418 patients with brucellosis during the study period, the highest incidence of the disease was in 2013 and the lowest in 2009, with incidence rates of 106 and 14.8 per 100,000 populations, respectively. In total, 65.8% of cases were males and 34.2% were females; 86.6% of the cases lived in rural and 13.4% in urban areas.

Discussion and Conclusions: Although the incidence of brucellosis has been increasing in recent years, it has a more increasing trend than the national average in Tiran and Karvan city. Provincial authorities in this field need to pay particular attention, and since most of the patients’ populations live in rural areas, there should also be public participation and intersectional collaboration to control brucellosis, with emphasis the role of health workers and health centers in disease control.